P171 Subfertility in young patients with Crohn′s disease. A case-control study

Abstract Background Inflammatory bowel disease (IBD) commonly affects women and men during the reproductive years.The effect of burden on fertility in these patients is a common concern for them. ECCO guidelines establish that active associated with decreased but studies regarding this topic are low quality outdated. Aims to investigate CD fertility, studying ovarian reserve as well global Sertoli cell function men, - To compare results healthy control group. (HC) assess related factors subfertility males CD. Methods This was cross-sectional, prospective case-control study, including patients, aged 18-40 years-old, HC matched by gender age (ratio 2:1). Morning baseline IB measured using ELISA. Serum anti-Müllerian hormone (AMH) ECLIA. Sociodemographic phenotypic features controls were collected.Subfertility defined < 89pg/mL, AMH <1.66 ug/L 0-24 years old group; <1.18 25-29 <0.67 30-34 <0.77 35-39 <0.01 40-44 <2 under 40 considered low. Results A total 163 individuals included: 83 (58 CD, median 28 old, RIQ 24-36; 25 HC, 31 26-37) 80 (50 26 21-36; 30 28, 26-32). Sedentary lifestyle more frequent vs (46% 3,3%, p<0,001). 24% 8% had clinical activity (IHB >4). Low (<2ug/L) older than HC: 95% (18/19) 44% (4/9) p=0.001, an OR presenting 2 3.28 (IC 95%, 1.6-6.4) >30 old. The average serum level similar between [1.83 (1.04-3.34) vs. 2.74 (1.05-4.12) g/L, p=0.4]. Abnormal rate rank not different groups population (11/50, 22% EC 7/30, 23% CS, p=0.9,). levels significantly lower [169 (140-217) 232 (178-274) p=0.001]. <89 pg/mL detected any 6% (n=3) In multivariate analysis, only no association or treatments found. Conclusion Women have higher risk general (<2).These data could be helpful at council desire progeny. concentration compared HC.